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I had a very poor diet for the first 20 years of my life, which did not set me up with a very healthy colon. Even after following naturopathic principles (a high proportion of fruits, vegetables and whole-grains) for many years, I still had a tendency to sluggishness in that department, and when I was in my 50s I began noticing some arthritic tenderness in my finger joints.
What I did cured this completely, and it never came back.